Conference Abstract
ACTG 076 - Making the Transfer from the Clinical Setting to the
Real World. B Sims, A Burgess. Washington University School of Medicine.
Poster Presentation
Category: Treatment & Health
Presentation Date & Time: 03/24/98 12:00:00
Great strides have been made in the battle against HIV. This was shown in
the findings of AIDS Clinical Trial Group (ACTG) 076. Perinatal transmission sharply
decreases with the use of zidovudine (ZDV) during pregnancy, delivery, and for newborn
administration. The Helena Hatch Special Care Center (HHSCC) at Washington University
School of Medicine is funded by a Special Projects of National Significance award. Using a
one-stop-shop multidisciplinary team approach, HHSCC provides comprehensive medical and
psychosocial care to 85% of all known women with HIV in the St. Louis metropolitan area.
Ninety percent of these women represent the changing face of HIV today: single-head of
household, economically disadvantaged, women of color. HHSCC has constructed guidelines
and measures to ensure that the ACTG 076 protocol is implemented in communities where lack
of resources and general distrust of medical institutions are major barriers to receiving
the most basic health care. The guidelines focus on: 1) increased coordination between
Pediatric and Adult Infectious Disease specialties through joint case conferencing, 2)
Pregnancy Process checklists, 3) peer support and 4) close patient/provider contact in the
home, hospital and outpatient clinic. The rate of vertical transmission for women of HHSCC
before implementation of ACTG 076 and the HHSCC guidelines in 1994 was 44.4%. With the use
of the ACTG 076 protocol and the HHSCC guidelines, the vertical transmission rate dropped
to 9% in 1995 and 0% in 1996. We recommend replication of HHSCC guidelines in other
programs for use in implementing ACTG 076 in multidisciplinary health care sites that
serve women with HIV. The guidelines can also be used in broadening reproductive health
counseling.
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